The LOEWE research cluster PreBionics has set itself the objective of gaining a better understanding of the changes in tissue mechanics caused by ageing and illness. To that end, the researchers analyse soft tissue at the macroscopic, cellular and molecular levels. Using computer simulation techniques, for example, they analyse mechanical effects produced by supportive structures (seating systems, knee prostheses, implants, stents, etc.), deformations of blood vessels caused by movement, the mechanics of tumours and the effect of compressive forces for the formation of cartilage cells. Other research topics include the characterisation of the mechanical features of aortae and aortic aneurysms, the mechanics of the jaw, teeth and dental implants, and forces that affect people on bus journeys. The acquisition of external funds has secured the future of many of the projects already begun in the research cluster.