The costs of developing new medicines are high. In cooperation with industry and academic groups, the LOEWE research centre Translational Medicine and Pharmacology TMP has set its sights on helping to cut development costs. At the interface between preclinical research and clinical development and trials, the aim is to ascertain the effectiveness and safety of pharmaceutical substances as quickly as possible and hence to raise the success rates of clinical development. The LOEWE research centre is continuing and expanding the work begun in the LOEWE research cluster Applied Pharmaceutical Research (2012 – 2014). That includes the further strategic development of the Translational Medicine and Pharmacology project group TMP at the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), which is ultimately intended to become the first Fraunhofer Institute in Frankfurt. At the research centre, the Fraunhofer project group TMP works closely with the participating groups at Frankfurt’s Goethe University and at the Max Planck Institute for Heart and Lung Research in Bad Nauheim.