TRABITA Transient Bindingpockets for Research and Development

© Luis Vollmers

Usually, drug molecules bind to specific therapeutic target proteins and thereby regulate their activity. Those proteins remain in their native conformation, however they form transient binding pockets temporarily. Often, drugs targeting these transient binding pockets have higher selectivity amongst other advantages, but on the downsides they are harder to discover.

The interdisciplinary consortium TRABITA was founded to facilitate the development of new therapeutic drugs for transient binding pockets. The project is supported by the Hessian Ministry of Science and Art, i.e. the LOEWE-Funding.

The project is designed to last for four years and is coordinated by the TU Darmstadt. The close cooperation with scientists of the h_da and of the Goethe-University is essential for the success of the project.

LOEWE Research Cluster


  • Darmstadt University of Technology (lead management)
  • Goethe University Frankfurt
  • University of Applied Sciences Darmstadt

Fields of study

  • Biophysics
  • Chemistry (protein models)
  • Chemistry (chemical tools)

Funding period


Project Coordinator

  • Professor Felix Hausch, Darmstadt University of Technology
  • Professor Dr Stefan Knapp (Co-Speaker), Goethe University Frankfurt


  • Darmstadt
  • Frankfurt am Main

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