The human brain is made of billions of nerve cells. Higher brain activity such as cognition, language or memory is based on neuronal coordination, the coordinated exchange of signals between individual nerve cells and groups of nerve cells. If this coordination is disrupted, brain disorders occur. NeFF is analysing neuronal coordination in schizophrenia and autism as well as in Alzheimer’s disease and multiple sclerosis. The scientists in the LOEWE research cluster are trying to determine indicators that will enable early diagnosis and allow therapeutic effects to be measured. To that end, they combine basic research with clinical neuroscience and mathematical modelling. In the field of neuromodulation, NeFF’s aim is to continue the work in a DFG Collaborative Research Centre (CRC). In a CRC set up together with the Johannes Gutenberg University in Mainz, for which a full proposal is being prepared, the focus is on resilience: hardly any research has so far been conducted into the human ability to resist psychiatric and neurological diseases, which is of extreme clinical relevance.