The LOEWE Centre for Cell and Gene Therapy aims to develop innovative cell and gene therapy procedures for more effective and safer clinical application. Scientists at the Centre work on deciphering molecular mechanisms underlying regenerative processes mediated by stem cells and genetic reprogramming, on elucidating the potential use of immunocompetent cells for treatment of malignant diseases, and on delineating the genetic basis for leukemias and immune deficiencies. Clinical applications range from cell-based regenerative therapies of cardiovascular diseases to gene therapy for selected immunodeficiencies and to immune cell-stimulated treatment of cancer.